Enterococcus faecalis Mutations Affecting Virulence in the Caenorhabditis elegans Model Host-Reference-Cited by-同舟云学术

Enterococcus faecalis Mutations Affecting Virulence in the Caenorhabditis elegans Model Host

Published:2007-05 Issue:5 Volume:75 Page:2634-2637
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Maadani Arash¹,Fox Kristina A.¹,Mylonakis Elftherios²,Garsin Danielle A.¹

Affiliation:

1. Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas

2. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts

Abstract

ABSTRACT Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans . The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01372-06

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