2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase

Abstract

ABSTRACTAs part of our efforts aimed at searching for new antiparasitic agents, the effect of representative 2-alkylaminoethyl-1,1-bisphosphonic acids onTrypanosoma cruzisqualene synthase (TcSQS) was investigated. These compounds had proven to be potent inhibitors ofT. cruzi. This cellular activity had been associated with an inhibition of the enzymatic activity ofT. cruzifarnesyl diphosphate synthase. 2-Alkylaminoethyl-1,1-bisphosphonic acids appear to have a dual action, since they also inhibitTcSQS at the nanomolar range.