Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors-Reference-Cited by-同舟云学术

Susceptibilities of Simian Immunodeficiency Virus to Protease Inhibitors

Published:2003-05 Issue:5 Volume:47 Page:1756-1759
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Giuffre Angelica C.¹,Higgins Joanne¹,Buckheit Robert W.²,North Thomas W.¹³

Affiliation:

1. Center for Comparative Medicine

2. Southern Research Institute, Fredrick, Maryland 21701

3. Department of Veterinary Molecular Biosciences, University of California, Davis, Davis, California 95616

Abstract

ABSTRACT We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means ± standard deviations) of 39 ± 8, 55 ± 3, and 13 ± 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 ± 4, 47 ± 10, and 25 ± 14 nM, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.5.1756-1759.2003

Reference47 articles.

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