Affiliation:
1. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA
Abstract
It is puzzling why
Mycobacterium tuberculosis
(Mtb) cannot grow on glycerol at acidic pH, as it has a carbon source and oxygen, everything it needs to grow. In this study, we found that Mtb limits uptake of glycerol at acidic pH to restrict its growth and that mutations in
ppe51
promote uptake of glycerol at acidic pH and enable growth.
Funder
HHS | National Institutes of Health
AgBioResearch, Michigan State University
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
4 articles.
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