Affiliation:
1. Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania
Abstract
A study was undertaken to determine whether virulence in mice could be used to assess the pathogenicity of a variety of
Escherichia coli
serotypes. Sixty-one
E. coli
strains isolated from animals, poultry, or humans were serotyped to determine their O, K, and H antigens, and were administered to mice via the intraperitoneal route with and without a mucin adjuvant. The
ld
50
dose was then determined for each serotype. The results indicated that the source of the serotype may be associated with virulence for mice. Serotypes isolated from nonenteric, systemic sources showed a greater virulence for mice inoculated intraperitoneally than did the enteric and the nonenteric, nonsystemic (localized) isolates. It was observed that not all serotypes belonging to a specific serogroup were virulent for mice and that the presence or absence of a K antigen had no effect on the virulence of strains of one serotype.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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