Coding-Complete Genome Sequences of 11 SARS-CoV-2 B.1.1.7 and B.1.351 Variants from Metro Manila, Philippines

Author:

Velasco John Mark12ORCID,Chinnawirotpisan Piyawan1ORCID,Valderama Maria Theresa1,Joonlasak Khajohn1,Manasatienkij Wudtichai1,Huang Angkana1,Diones Paula Corazon1,Navarro Fatima Claire3,Vila Vicente3,Tabinas Henry3,Chua Domingo3,Fernandez Stefan1,Jones Anthony1,Klungthong Chonticha1

Affiliation:

1. U.S. Army Medical Directorate—Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

2. University of the Philippines Manila, Ermita, Manila, Philippines

3. V. Luna Medical Center, Armed Forces of the Philippines Health Service Command, Quezon City, Philippines

Abstract

Here, we report the complete genome sequences of 11 SARS-CoV-2 variants from the Philippines. Lineage analysis showed 3 B.1.1.7 and 8 B.1.351 sequences. One B.1.1.7 sequence contained two additional mutations, F318N and V320F, with V320F located in the receptor-binding domain of the S1 subunit.

Funder

DOD | MHS | Armed Forces Health Surveillance Branch

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

Reference24 articles.

1. A Novel Coronavirus from Patients with Pneumonia in China, 2019

2. Philippine Genome Center. 2021. PGC SARS-CoV-2 bulletin no. 6: first case of the new variant under lineage B.1.1.7 detected in the Philippines. https://pgc.up.edu.ph/pgc-sars-cov-2-bulletin-no-6/.

3. DOH. 2021. Philippine genomic biosurveillance detects SARS-CoV-2 UK variant. https://doh.gov.ph/doh-press-release/PH-GENOMIC-BIOSURVEILLANCE-DETECTS-SARS-COV-2-UK-VARIANT.

4. DOH. 2021. Sustained biosurveillance efforts detect 6 B.1.351 cases 30 B.1.1.7 cases and 2 cases with mutations of interest. https://doh.gov.ph/doh-press-release/SUSTAINED-BIOSURVEILLANCE-EFFORTS-DETECT-6-B-1-351-CASES-30-B-1-1-7-CASES-AND-2-CASES-WITH-MUTATIONS-OF-INTEREST.

5. DOH. 2021. Continuing biosurveillance detects additional B.1.1.7 and B.1.351 cases and P.1. variant case. https://doh.gov.ph/doh-press-release/CONTINUING-BIOSURVEILLANCE-DETECTS-ADDITIONAL-B-1-1-7-AND-B-1-351-CASES-AND-P-1-VARIANT-CASE.

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