Effect of Hemagglutinin Glycosylation on Influenza Virus Susceptibility to Neuraminidase Inhibitors-Reference-Cited by-同舟云学术

Effect of Hemagglutinin Glycosylation on Influenza Virus Susceptibility to Neuraminidase Inhibitors

Published:2005-10 Issue:19 Volume:79 Page:12416-12424
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mishin Vasiliy P.¹,Novikov Dmitri¹,Hayden Frederick G.¹²,Gubareva Larisa V.¹

Affiliation:

1. Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia

2. Department of Pathology, School of Medicine, University of Virginia, Charlottesville, Virginia

Abstract

ABSTRACT Inhibition of neuraminidase (NA) activity prevents release of progeny virions from influenza-infected cells and removal of neuraminic (sialic) acid moieties from glycans attached to hemagglutinin (HA). Neuraminic acid moieties situated near the HA receptor-binding site can reduce the efficiency of virus binding and decrease viral dependence on NA activity for replication. With the use of reverse genetics technique, we investigated the effect of glycans attached at Asn 94a, 129, and 163 on the virus susceptibility to NA inhibitors in MDCK cells and demonstrated that the glycan attached at Asn 163 plays a dominant role in compensation for the loss of NA activity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.19.12416-12424.2005

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