Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual <i>Plasmodium falciparum</i>-Reference-Cited by-同舟云学术

Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum

Published:2024-01-09 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chery-Karschney Laura¹^ORCID,Patrapuvich Rapatbhorn²,Mudeppa Devaraja Gouda¹,Kokkonda Sreekanth¹,Chakrabarti Rimi¹³^ORCID,Sriwichai Patchara⁴,O'Connor Roberta M.⁵,Rathod Pradipsinh K.¹,White John¹

Affiliation:

1. Department of Chemistry, University of Washington, Seattle, Washington, USA

2. Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa, India

4. Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

5. Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA

Abstract

ABSTRACT Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Complementary and Integrative Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00684-23

Reference19 articles.

1. WHO. 2022. World malaria report. World Health Organization, Geneva.

2. Evidence of Artemisinin-Resistant Malaria in Africa

3. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

4. Antibiotics for Emerging Pathogens

5. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019