Population Pharmacokinetics of Caspofungin among Extracorporeal Membrane Oxygenation Patients during the Postoperative Period of Lung Transplantation-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Caspofungin among Extracorporeal Membrane Oxygenation Patients during the Postoperative Period of Lung Transplantation

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Qianlin¹²^ORCID,Zhang Zhu¹²,Liu Donglin¹³,Chen Wenqian⁴,Cui Gang⁴,Li Pengmei⁴,Zhang Xianglin⁴,Li Min¹,Zhan Qingyuan¹²,Wang Chen¹²

Affiliation:

1. Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing, China

2. Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

3. Graduate School of Capital Medical University, Beijing, China

4. Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China

Abstract

Little is known about the influence of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics (PK) of caspofungin. The aim of this study was to describe population PK of caspofungin in patients with and without ECMO during the postoperative period of lung transplantation (LTx) and to investigate covariates influencing caspofungin PK. We compared ECMO patients with non-ECMO patients, and patients before and after ECMO weaning as self-controls, to analyzed changes in caspofungin PK. Eight serial blood samples were collected from each patient for PK analysis.

Funder

National Natural Science Foundation of China

MOST | National Key Scientific Instrument and Equipment Development Projects of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00687-20

Reference32 articles.

1. The epidemiology and outcomes of invasiveCandidainfections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)

2. Epidemiology of Invasive Mold Infections in Lung Transplant Recipients