Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops-Reference-Cited by-同舟云学术

Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops

Published:2016-11 Issue:11 Volume:60 Page:6896-6898
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Neoh Chin Fen¹²,Leung Lok³,Chan Elsie⁴,Al-Badriyeh Daoud⁵,Fullinfaw Robert O.⁶,Jhanji Vishal⁴⁷,Vajpayee Rasik B.⁴,Davies Geoffrey E.³⁸,Stewart Kay²,Kong David C. M.²

Affiliation:

1. Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia

2. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

3. Department of Pharmacy, Royal Victorian Eye and Ear Hospital (RVEEH), East Melbourne, Victoria, Australia

4. Corneal Unit, Royal Victorian Eye and Ear Hospital (RVEEH), Centre for Eye Research Australia, East Melbourne, Victoria, Australia

5. College of Pharmacy, Qatar University, Doha, Qatar

6. Special Chemistry, Melbourne Health Pathology, The Royal Melbourne Hospital, Parkville, Victoria, Australia

7. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, China

8. Health Systems Program Office, Integrated Soldier Systems Branch, Land Systems Division, Capability Acquisition and Sustainment Group, Department of Defence, Victoria Barracks Melbourne, Southbank, Victoria, Australia

Abstract

ABSTRACT Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC 90 values for typical fungi that cause keratitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00683-16

Reference15 articles.

1. Voriconazole in the Management of Alternaria Keratitis

2. Fungal infections of the cornea

3. Clinical utility of caspofungin eye drops in fungal keratitis

4. In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens

5. Penetration of Voriconazole, 1%, Eyedrops Into Human Aqueous Humor

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antifungal susceptibility profiles for fungal isolates from corneas and contact lenses in the United Kingdom;Eye;2023-09-08

2. Oral voriconazole monotherapy for fungal keratitis: efficacy, safety, and factors associated with outcomes;Frontiers in Medicine;2023-05-11

3. Antifungal susceptibility profiles for fungal isolates from corneas and contact lenses in the United Kingdom;2023-05-11

4. Antiamoebic Susceptibility in Acanthamoeba Keratitis: Comparison of Isolates From South India and Northern California;Cornea;2022-08-24

5. Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement;Journal of Fungi;2022-02-21