Whole-Genome Sequences of Four Mycobacterium bovis BCG Vaccine Strains

Author:

Pan Yuanlong12,Yang Xi12,Duan Jia12,Lu Na1,Leung Andrea S.3,Tran Vanessa3,Hu Yongfei1,Wu Na12,Liu Di1,Wang Zhiming12,Yu Xuping4,Chen Chen5,Zhang Yuanyuan5,Wan Kanglin5,Liu Jun3,Zhu Baoli1

Affiliation:

1. Microbial Genome Research Center, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China

2. Graduate University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China

3. Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada

4. Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310029, People's Republic of China

5. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China

Abstract

ABSTRACT Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only vaccine available against tuberculosis (TB). A number of BCG strains are in use, and they exhibit biochemical and genetic differences. We report the genome sequences of four BCG strains representing different lineages, which will help to design more effective TB vaccines.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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