Affiliation:
1. Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy
Abstract
ABSTRACT
The
mmr
gene, cloned from
Mycobacterium tuberculosis
, was shown to confer to
Mycobacterium smegmatis
resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [
3
H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
85 articles.
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