Affiliation:
1. Medical Service, Veterans Administration Hospital, Minneapolis, Minnesota 55417 and Departments of Medicine and Microbiology, University of Minnesota, Minneapolis, Minnesota 55455
Abstract
A photometric method was used to measure the bactericidal kinetics for
Brucella abortus
of freshly drawn rabbit blood during the time before clotting. This antibrucellar activity varied between rabbits in different immunologic states. Nonimmunized rabbits had moderate bactericidal activity after a lag of about 2 min. The blood of some immunized rabbits gave an immediate and strong kill, but in certain other immunized rabbits, especially when hyperimmunized, the bactericidal activity was inhibited. It appeared that serum bactericidins and complement are sometimes as active in unclotted blood as they are in serum. However, this bactericidal activity can be either increased or neutralized by immunization. The prozone bactericidal inhibition phenomenon (Neisser-Wechsberg) found in immune serum may, in fact, reflect inhibition taking place in vivo. Inhibition of the bactericidal activity in blood can contribute to the persistence of chronic infections and individual variations in resistance.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
8 articles.
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