Biennial Upsurge and Molecular Epidemiology of Enterovirus D68 Infection in New York, USA, 2014 to 2018

Author:

Gilrane Victoria L.1,Zhuge Jian2,Huang Weihua1,Nolan Sheila M.3,Dhand Abhay4,Yin Changhong1,Salib Christian12,Shakil Faariah1,Engel Helen2,Fallon John T.12,Wang Guiqing12

Affiliation:

1. Department of Pathology, New York Medical College, Valhalla, New York, USA

2. Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, New York, USA

3. Department of Pediatrics, Division of Infectious Disease, New York Medical College and Maria Fareri Children’s Hospital, Valhalla, New York, USA

4. Department of Medicine, Division of Infectious Disease, New York Medical College, Valhalla, New York, USA

Abstract

Enterovirus D68 (EV-D68) infection has been associated with outbreaks of severe respiratory illness and increased cases of nonpolio acute flaccid myelitis. The patterns of EV-D68 circulation and molecular epidemiology are not fully understood. In this study, nasopharyngeal (NP) specimens collected from patients in the Lower Hudson Valley, New York, from 2014 to 2018 were examined for rhinovirus/enterovirus (RhV/EV) by the FilmArray respiratory panel. Selected RhV/EV-positive NP specimens were analyzed using two EV-D68-specific real-time RT-PCR assays, Sanger sequencing and metatranscriptomic next-generation sequencing.

Funder

New York Medical College

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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