DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals-Reference-Cited by-同舟云学术

DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals

Published:2022-06-22 Issue:12 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Dochnal Sara¹,Merchant Husain Y.²,Schinlever Austin R.¹,Babnis Aleksandra¹,Depledge Daniel P.²^ORCID,Wilson Angus C.²^ORCID,Cliffe Anna R.¹^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA

2. Department of Microbiology, New York University School of Medicine, New York, New York, USA

Abstract

Herpes simplex virus-1 (HSV-1) enters a latent infection in neurons and periodically reactivates. Reactivation manifests as a variety of clinical symptoms.

Funder

HHS | NIH | National Institute of General Medical Sciences

Deutsches Zentrum für Infektionsforschung

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Owens Family Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00508-22

Reference120 articles.

1. Distribution of Herpes Simplex Virus Type 1 and Varicella Zoster Virus in Ganglia of the Human Head and Neck

2. Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction

3. Recovery of Herpes-Simplex Virus from Human Trigeminal Ganglions

4. Isolation of Latent Herpes Simplex Virus from the Superior Cervical and Vagus Ganglions of Human Beings

5. Herpes Simplex Virus Latency Is Noisier the Closer We Look

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