Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity-Reference-Cited by-同舟云学术

Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lin Jonah¹,Law Ryan¹,Korosec Chapin S.²,Zhou Christine¹,Koh Wan Hon¹³,Ghaemi Mohammad Sajjad⁴,Samaan Philip³⁵,Ooi Hsu Kiang⁴^ORCID,Matveev Vitaliy³,Yue FengYun³,Gingras Anne-Claude⁶⁷,Estacio Antonio⁸,Buchholz Megan⁹,Cheatley Patti Lou⁹,Mohammadi Avid³,Kaul Rupert³,Pavinski Katerina¹⁰,Mubareka Samira¹¹,McGeer Allison J.⁶,Leis Jerome A.¹¹,Heffernan Jane M.²,Ostrowski Mario¹³¹²⁸⁵^ORCID

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, Ontario, Canada

2. Modelling Infection and Immunity Lab, Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada

3. Department of Medicine, University of Toronto, Toronto, Ontario, Canada

4. Digital Technologies Research Centre, National Research Council Canada, Toronto, Ontario, Canada

5. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

6. Lunenfeld-Tanenbaum Research Institute at Mt. Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada

7. Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada

8. Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Unity Health, Toronto, Ontario, Canada

9. Apheresis Unit, Kidney and Metabolism Program, St. Michael’s Hospital, Unity Health, Toronto, Ontario, Canada

10. Department of Laboratory Medicine, St. Michael’s Hospital, Unity Health, Toronto, Ontario, Canada

11. Sunnybrook Health Sciences Centre and Research Institute, Toronto, Ontario, Canada

12. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

Abstract

Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence of T cell memory at least 1 year after infection. Our findings should inform future strategies to induce T cell vaccines against SARS-CoV-2 and other coronaviruses.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Ontario HIV Treatment Network

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00509-22

Reference62 articles.

1. WHO. 2021. WHO coronavirus (COVID-19) dashboard. https://covid19.who.int/.

2. Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel