Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria-Reference-Cited by-同舟云学术

Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria

Published:2014-02 Issue:2 Volume:82 Page:818-829
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Armistead Jennifer S.¹,Morlais Isabelle²,Mathias Derrick K.¹,Jardim Juliette G.¹,Joy Jaimy¹,Fridman Arthur³,Finnefrock Adam C.³,Bagchi Ansu³,Plebanski Magdalena⁴,Scorpio Diana G.⁵,Churcher Thomas S.⁶,Borg Natalie A.⁷,Sattabongkot Jetsumon⁸,Dinglasan Rhoel R.¹

Affiliation:

1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and the Malaria Research Institute, Baltimore, Maryland, USA

2. Laboratoire de Recherche sur le Paludisme, Institut de Recherche pour le Développement IRD-OCEAC, Yaoundé, Cameroon

3. Merck Research Laboratories, West Point, Pennsylvania, USA

4. Department of Immunology, Monash University, Alfred Hospital, Melbourne, Australia

5. Department of Molecular and Comparative Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

6. Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

7. Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

8. Mahidol Vivax Research Center, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

ABSTRACT Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrated that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in countries to which malaria is endemic. Using a biochemical and immunological approach, we determined that the mechanism of action for this phenomenon stems from antibody recognition of a single protective epitope on AnAPN1, which we found to be immunogenic in murine and nonhuman primate models and highly conserved among anophelines. These data indicate that AnAPN1 meets the established target product profile for TBVs and suggest a potential key role for an AnAPN1-based panmalaria TBV in the effort to eradicate malaria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01222-13

Reference57 articles.

1. World Health Organization. 2012. World Malaria Report. World Health Organization, Geneva, Switzerland.

2. Global malaria mortality between 1980 and 2010: a systematic analysis

3. A review of malaria vaccine clinical projects based on the WHO rainbow table

4. A Research Agenda to Underpin Malaria Eradication

5. Transmission blocking malaria vaccines

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants;PLOS ONE;2024-07-05

2. Targeting plasmodium α-tubulin-1 to block malaria transmission to mosquitoes;Frontiers in Cellular and Infection Microbiology;2023-03-16

3. Plasmodium vivax vaccine: What is the best way to go?;Frontiers in Immunology;2023-01-16

4. Vector-Parasite Interactions and Malaria Transmission;Mosquito Research - Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies;2023-01-04

5. Malaria Vaccines;Infectious Diseases;2023