Contribution of Gelatinase, Serine Protease, and fsr to the Pathogenesis of Enterococcus faecalis Endophthalmitis-Reference-Cited by-同舟云学术

Contribution of Gelatinase, Serine Protease, and fsr to the Pathogenesis of Enterococcus faecalis Endophthalmitis

Published:2004-06 Issue:6 Volume:72 Page:3628-3633
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Engelbert Michael¹,Mylonakis Eleftherios²,Ausubel Frederick M.³⁴,Calderwood Stephen B.²⁵,Gilmore Michael S.¹⁶

Affiliation:

1. Department of Microbiology and Immunology

2. Division of Infectious Diseases

3. Department of Molecular Biology, Massachusetts General Hospital

4. Department of Genetics

5. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts

6. Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Abstract

ABSTRACT Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.6.3628-3633.2004

Reference19 articles.

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