Affiliation:
1. Division of Infectious Diseases, Department of Internal Medicine
2. Center for the Study of Emerging and Reemerging Pathogens
3. Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030
Abstract
ABSTRACT
Endocarditis isolates of
Enterococcus faecalis
produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (
P
< 0.0001).
esp
was not required, but its presence was associated with higher amounts of biofilm (
P
< 0.001). Mutants disrupted in
dltA
,
efaA
,
ace
,
lsa
, and six two-component regulatory systems were largely unaltered, while disruptions in
epa
,
atn
,
gelE
, and
fsr
resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (
P
< 0.0001).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
256 articles.
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