Affiliation:
1. CIHR Group in Matrix Dynamics and Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
Abstract
ABSTRACT
Treponema denticola
and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference17 articles.
1. Arora, P. D., L. Silvestri, B. Ganss, J. Sodek, and C. A. G. McCulloch. 2000. Mechanism of cyclosporin-induced inhibition of intracellular collagen degradation. J. Biol. Chem.276:14100-14109.
2. DeFilippo, A. B., R. P. Ellen, and C. A. G. McCulloch. 1995. Induction of cytoskeletal rearrangements and loss of volume regulation in epithelial cells by Treponema denticola. Arch. Oral Biol.40:199-207.
3. Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola
4. Cytopathic Effects of the Major Surface Protein and the Chymotrypsinlike Protease of
Treponema denticola
5. Fenno, J. C., and B. C. McBride. 1998. Virulence factors of oral treponemes. Anaerobe4:1-17.
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