Affiliation:
1. Roche Institute of Molecular Biology, Nutley, New Jersey 07110
2. The Kitasato Institute and Kitasato University, Minato-Ku, Tokyo, Japan
Abstract
We examined the effect of leucomycins, leucomycin derivatives, and other 16-membered macrolides (tylosin, niddamycin, spiramycin I, and spiramycin III) on [
14
C]erythromycin binding to ribosomes. Results of these studies enabled determination of the association and dissociation constants for the binding of each of these compounds to
Escherichia coli
ribosomes. In addition, the binding of the leucomycins and the leucomycin derivatives to ribosomes in general correlated with their antimicrobial activity.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
21 articles.
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