Role of Defective Thymic Function in Onset of Ganciclovir-Resistant Cytomegalovirus after Cord Blood Transplantation-Reference-Cited by-同舟云学术

Role of Defective Thymic Function in Onset of Ganciclovir-Resistant Cytomegalovirus after Cord Blood Transplantation

Published:2012-12 Issue:12 Volume:19 Page:1994-1998
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Cantisán Sara¹,Martín Carmen²,Romero-Sánchez María C.³,Ferrando-Martínez Sara³⁴,Martínez Francisco²,Rivero Antonio¹,Torres Antonio²,Solana Rafael¹,Torre-Cisneros Julián¹

Affiliation:

1. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC) - Reina Sofia University Hospital-University of Cordoba (UCO), Cordoba, Spain

2. Department of Hematology and Hematopoietic Stem Cell Transplantation Unit, Reina Sofia University Hospital-IMIBIC-University of Cordoba, Cordoba, Spain

3. Laboratory of Immunovirology, Biomedicine Institute of Seville (IBIS), Service of Infectious Diseases, Virgen del Rocío University Hospital, Seville, Spain

4. Laboratory of Molecular Immuno-Biology, Gregorio Marañón University Hospital, Madrid, Spain

Abstract

ABSTRACT A case of recurrent cytomegalovirus reactivations in a cytomegalovirus-seropositive woman who received allogeneic cord blood transplantation is described. Thirteen months posttransplantation, her CD3 + T cell count was extremely low whereas natural killer cells represented 66% of her total lymphocytes. She showed defective thymic function that might contribute to the onset of valganciclovir resistance.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00407-12

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