Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries-Reference-Cited by-同舟云学术

Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries

Published:2017-01 Issue:1 Volume:24 Page:
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Mwila Katayi¹,Chilengi Roma¹²,Simuyandi Michelo¹,Permar Sallie R.³,Becker-Dreps Sylvia²

Affiliation:

1. Centre for Infectious Disease Research in Zambia, Lusaka, Zambia

2. Department of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Pediatrics, Human Vaccine Institute, Duke University, Durham, North Carolina, USA

Abstract

ABSTRACT The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00405-16

Reference89 articles.

1. Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000–2013

2. Rotavirus vaccines WHO position paper—January 2013;WHO;Wkly Epidemiol Rep,2013

3. Oral Rotavirus Vaccines: How Well Will They Work Where They Are Needed Most?