Inflammatory effects of Salmonella typhimurium porins-Reference-Cited by-同舟云学术

Inflammatory effects of Salmonella typhimurium porins

Published:1990-10 Issue:10 Volume:58 Page:3183-3186
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Galdiero F¹,Tufano M A¹,Galdiero M¹,Masiello S¹,Di Rosa M¹

Affiliation:

1. Istituto di Microbiologia, I Facoltà di Medicina e Chirurgia, Università di Napoli, Naples, Italy.

Abstract

The inflammatory activity of porins purified from Salmonella typhimurium has been investigated. Porins (0.3 to 30 micrograms) injected into the rat paw induced a dose-related edema that was not due to lipopolysaccharide contamination and did not appear to be dependent on the activation of the complement system. The edema induced by 30 micrograms of porins was comparable to that caused by 1 mg of carrageenin and was inhibited by indomethacin (5 mg/kg) and dexamethasone (0.1 mg/kg). Porins (1 to 10 micrograms/ml) induced a concentration-related release of histamine from rat peritoneal cells. These results are discussed in the light of the possible pathogenic role of porins in infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.58.10.3183-3186.1990

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