Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6)-Reference-Cited by-同舟云学术

Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6)

Published:1990-01 Issue:1 Volume:58 Page:269-271
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Flesch I E¹,Kaufmann S H¹

Affiliation:

1. Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.

Abstract

Mononuclear phagocytes provide the major habitat of intracellular bacteria, including Mycobacterium tuberculosis and Mycobacterium bovis. The capacity of B-cell stimulatory factor 2 (interleukin-6 [IL-6]) to activate tuberculostatic functions was investigated by using murine bone marrow-derived macrophages (BMM phi). BMM phi stimulated with recombinant IL-6 and subsequently infected with M. bovis organisms failed to inhibit mycobacterial growth. In contrast, marked tuberculostasis was induced by IL-6 in BMM phi that were already infected with M. bovis, indicating that IL-6 has a macrophage-activating function.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.58.1.269-271.1990

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