Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery-Reference-Cited by-同舟云学术

Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Keniya Mikhail V.¹,Ruma Yasmeen N.¹,Tyndall Joel D. A.²,Monk Brian C.¹

Affiliation:

1. Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

2. School of Pharmacy, University of Otago, Dunedin, New Zealand

Abstract

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to the emergence of drug-resistant fungal pathogens.

Funder

Manatu Hauora | Health Research Council of New Zealand

Royal Society of New Zealand | Marsden Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01131-18

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