<i>cis</i> -Acting Element at the 5' Noncoding Region of Tacaribe Virus S RNA Modulates Genome Replication-Reference-Cited by-同舟云学术

cis -Acting Element at the 5' Noncoding Region of Tacaribe Virus S RNA Modulates Genome Replication

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

D'Antuono Alejandra L.¹,Gallo Giovanna L.¹,Sepulveda Claudia²³,Fernández Jonás¹,Brignone Julia⁴,Gamboa Graciela⁴,Riera Laura⁴,Saavedra María del Carmen⁴,López Nora¹^ORCID

Affiliation:

1. Centro de Virología Humana y Animal, Consejo Nacional de Investigaciones Científicas y Técnicas—Universidad Abierta Interamericana, Buenos Aires, Argentina

2. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

3. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales, Consejo Nacional de Investigaciones Científicas y Técnicas—Universidad de Buenos Aires, Buenos Aires, Argentina

4. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui, ANLIS-Malbran, Ministerio de Salud de la Nación, Pergamino, Buenos Aires, Argentina

Abstract

The Mammarenavirus genus of the Arenaviridae family includes several members that cause severe hemorrhagic fevers associated with high morbidity and mortality rates, for which no FDA-approved vaccines and limited therapeutic resources are available. We provide evidence demonstrating the specific involvement of the TCRV S 5′ noncoding sequence adjacent to the viral promoter in replication.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00125-23

Reference41 articles.

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2. Tacaribe Virus, a New Agent Isolated from Artibeus Bats and Mosquitoes in Trinidad, West Indies *

3. Isolation of Tacaribe Virus, a Caribbean Arenavirus, from Host-Seeking Amblyomma americanum Ticks in Florida

4. Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018

5. Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

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