Pathological Characteristics of Echovirus 30 Infection in a Mouse Model-Reference-Cited by-同舟云学术

Pathological Characteristics of Echovirus 30 Infection in a Mouse Model

Published:2022-05-11 Issue:9 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Jichen¹²,Zhang Guoyan²,Sun Qiang²,Zhang Keyi²,Lu Huanhuan²,Xiao Jinbo²,Han Zhenzhi²,Zhao Hehe²,Xu Wenbo²³,Zhang Yong²³,Liu Zhijun¹

Affiliation:

1. Department of Medical Microbiology, Weifang Medical University, Weifang, People’s Republic of China

2. WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

3. Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

Abstract

Echovirus 30 (E30) infection causes a wide spectrum of diseases with mild symptoms, such as hand, foot, and mouth disease (HFMD), acute flaccid paralysis, and aseptic meningitis and other diseases, especially one of the most common pathogens causing aseptic meningitis outbreaks. We established a novel mouse model of E30 infection by inoculating neonatal mice with clinical isolates of E30 and observed the pathological changes induced by E30.

Funder

Natural Science Foundation of Beijing

Natural Science Foundation of China Youth Science Fund project

National Key R&D Program

Natural Science Foundation of Shandong Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00129-22

Reference43 articles.