Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity-Reference-Cited by-同舟云学术

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Published:2022-04-27 Issue:8 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Essalmani Rachid¹,Jain Jaspreet²,Susan-Resiga Delia¹,Andréo Ursula¹²,Evagelidis Alexandra¹,Derbali Rabeb Mouna¹,Huynh David N.¹,Dallaire Frédéric²,Laporte Mélanie²,Delpal Adrien³,Sutto-Ortiz Priscila³,Coutard Bruno⁴,Mapa Claudine⁵,Wilcoxen Keith⁵,Decroly Etienne³^ORCID,NQ Pham Tram²,Cohen Éric A.²⁶^ORCID,Seidah Nabil G.¹^ORCID

Affiliation:

1. Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada

2. Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada

3. AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France

4. Unité des Virus Émergents (UVE), Aix-Marseille University, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France

5. Boston Pharmaceuticals, Translational Research, Cambridge, Massachusetts, USA

6. Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada

Abstract

SARS-CoV-2, the etiological agent of COVID-19, has so far resulted in >6.1 million deaths worldwide. The spike protein (S) of the virus directs infection of the lungs and other tissues by binding the angiotensin-converting enzyme 2 (ACE2) receptor.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00128-22

Reference74 articles.

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3. The Science Underlying COVID-19