Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation-Reference-Cited by-同舟云学术

Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation

Published:2019-08-15 Issue:16 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bose Debojit¹,Neumann Alexander¹,Timmermann Bernd²,Meinke Stefan¹,Heyd Florian¹

Affiliation:

1. Institute of Chemistry and Biochemistry, Laboratory of RNA Biochemistry, Freie Universität Berlin, Berlin, Germany

2. Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany

Abstract

T cells are nodal players in the adaptive immune response against pathogens and malignant cells. Alternative splicing plays a crucial role in T cell activation, which is analyzed mainly at later time points upon stimulation. Here we have discovered a 2-h time window early after stimulation where optimal splicing efficiency or, more generally, gene expression efficiency is crucial for successful T cell activation.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00035-19

Reference49 articles.

1. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

2. CD8 T cell quiescence revisited

3. Differentiation of Effector CD4 T Cell Populations