Affiliation:
1. Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
Abstract
ABSTRACT
Interleukin-15 (IL-15), natural killer (NK) cells, and NK T (NKT) cells, components of the innate immune system, are known to contribute to defense against pathogens, including viruses. Here we report that IL-15
−/−
(NK
−
and NKT
−/+
) mice and RAG-2
−/−
/γ
c
−/−
(NK
−
and NKT
−
) mice that lack all lymphoid cells were very susceptible to vaginal infection with a low dose of herpes simplex virus type 2 (HSV-2). IL-15
−/−
and RAG-2
−/−
/γ
c
−/−
mice were 100-fold more susceptible and RAG-2
−/−
, CD-1
−/−
(NKT
−
), and gamma interferon (IFN-γ)
−/−
mice were 10-fold more susceptible to vaginal HSV-2 infection than control C57BL/6 mice. NK and/or NKT cells were the early source of IFN-γ in vaginal secretions following genital HSV-2 infection. This study demonstrates that IL-15 and NK-NKT cells are critical for innate protection against genital HSV-2.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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