Coexistence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces a Wild-Type Pattern of Secretion-Reference-Cited by-同舟云学术

Coexistence of Two Distinct Secretion Mutations (P5T and I97L) in Hepatitis B Virus Core Produces a Wild-Type Pattern of Secretion

Published:2003-07 Issue:13 Volume:77 Page:7673-7676
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chua Pong Kian¹,Wen Yu-Mei²,Shih Chiaho¹

Affiliation:

1. Center for Tropical Diseases, Department of Pathology, and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77555-0609

2. Department of Molecular Virology, Medical Center of Fudan University, Shanghai 200032, People's Republic of China

Abstract

ABSTRACT Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.13.7673-7676.2003

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