High Prevalence of Biocide Resistance Determinants in Staphylococcus aureus Isolates from Three African Countries-Reference-Cited by-同舟云学术

High Prevalence of Biocide Resistance Determinants in Staphylococcus aureus Isolates from Three African Countries

Published:2016-01 Issue:1 Volume:60 Page:678-681
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Conceição Teresa¹,Coelho Céline¹,de Lencastre Hermínia¹²,Aires-de-Sousa Marta³

Affiliation:

1. Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal

2. Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA

3. Escola Superior de Saúde da Cruz Vermelha Portuguesa (ESSCVP), Lisbon, Portugal

Abstract

ABSTRACT We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02140-15

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