Unstable Binary Capsulated Transformants in Pneumococcus-Reference-Cited by-同舟云学术

Unstable Binary Capsulated Transformants in Pneumococcus

Published:1969-06 Issue:3 Volume:98 Page:1073-1079
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bernheimer Harriet P.¹,Wermundsen Ingbritt E.¹

Affiliation:

1. Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

Abstract

Through transformation reactions, binary capsulated SI-III strains of pneumococci have been isolated that are unstable and lose the SI capsular genome at high frequency. The instability is caused by the specific mutation in the SIII capsular genome common to all of the unstable strains. In the family of strains studied, the SI capsular genome was integrated into the recipient chromosome in at least two loci: one apparently adjacent to the resident capsular genome and a second some distance from it. A hypothesis is presented to explain the instability of the strains on the basis of redundancy of genetic information.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.98.3.1073-1079.1969

Reference10 articles.

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3. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid;Burton K.;Biochem. J.,1966

4. Transformations allogenes du pneumocoque;Ephrussi-Taylor H.;Exptl. Cell Res.,1951

5. Unstable genetic transformation in Bacillus subtilis and the mode of inheritance in unstable clones;Iyer V. N.;J. Bacteriol.,1965

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