The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein-Reference-Cited by-同舟云学术

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein

Published:1996-01 Issue:1 Volume:70 Page:647-650
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Horvath C M¹,Darnell J E¹

Affiliation:

1. Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021, USA.

Abstract

Both of the latent transcription factors activated by alpha interferon or gamma interferon contain the Stat1 protein. The role of Stat1 in virus interference mediated by interferons was directly examined by using cultured cells expressing Stat1 protein and its variants. In the absence of Stat1, no antiviral state is established. Full complementation of the antiviral state requires full-length Stat1 which is phosphorylated on both tyrosine 701 and serine 727. The closely related signal transducer and activator of transcription protein Stat3 cannot substitute for the antiviral properties of Stat1.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.70.1.647-650.1996

Reference37 articles.

1. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway;Akira S.;Cell,1994

2. PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon;Clemens M. J.;J. Interferon Res.,1993

3. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins;Darnell J. E.;Science,1994

4. Friedman R. M. 1981. Interferons: a primer. Academic Press New York.

5. ISGF3, the transcriptional activator induced by interferon-alpha consists of multiple interacting polypeptide chains;Fu X.;Proc. Natl. Acad. Sci. USA,1990

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