Affiliation:
1. Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
Abstract
The spread of antimicrobial resistance genes (ARGs) among Gram-negative pathogens, including
Acinetobacter baumannii
, is primarily mediated by transferable plasmids; however, ARGs are frequently integrated into its chromosome. How ARG gets horizontally incorporated into the chromosome of
A. baumannii
, and whether it functions as a cause for further spread of ARG, remains unknown. Here, we demonstrated intercellular prophage-mediated transfer of chromosomal ARGs without direct cell-cell interaction in
A. baumannii
.
Funder
MEXT | Japan Society for the Promotion of Science
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
38 articles.
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