Affiliation:
1. Division of Biological Sciences, The University of Montana, Missoula, Montana 59812
Abstract
ABSTRACT
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent,
Borrelia burgdorferi
. Mutations in
parC
, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
11 articles.
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