Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks-Reference-Cited by-同舟云学术

Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks

Published:2005-10 Issue:10 Volume:49 Page:4396-4399
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Casey John¹,Cote Paul J.²,Toshkov Illia A.³,Chu Chung K.⁴,Gerin John L.²,Hornbuckle William E.³,Tennant Bud C.³,Korba Brent E.²

Affiliation:

1. Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C.

2. Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland

3. Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York

4. College of Pharmacy, University of Georgia, Athens, Georgia

Abstract

ABSTRACT In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.10.4396-4399.2005

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