AmpC and OprD Are Not Involved in the Mechanism of Imipenem Hypersusceptibility among Pseudomonas aeruginosa Isolates Overexpressing the mexCD - oprJ Efflux Pump-Reference-Cited by-同舟云学术

AmpC and OprD Are Not Involved in the Mechanism of Imipenem Hypersusceptibility among Pseudomonas aeruginosa Isolates Overexpressing the mexCD - oprJ Efflux Pump

Published:2005-11 Issue:11 Volume:49 Page:4763-4766
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wolter Daniel J.¹,Hanson Nancy D.¹,Lister Philip D.¹

Affiliation:

1. Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178

Abstract

ABSTRACT Pseudomonas aeruginosa strains that overexpress mexCD - oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.11.4763-4766.2005

Reference23 articles.

1. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant

2. Evidence for multiple forms of type I chromosomal beta-lactamase in Pseudomonas aeruginosa

3. Characterization of the MexC-MexD-OprJ Multidrug Efflux System in Δ mexA-mexB-oprM Mutants of Pseudomonas aeruginosa

4. Penicillin-binding protein 4 overproduction increases beta-lactam resistance in Staphylococcus aureus

5. Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa

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