Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection-Reference-Cited by-同舟云学术

Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chuang Fu-Kai¹,Huang Shih-Ming²,Liao Ching-Len³⁴,Lee An-Rong⁵,Lien Shu-Pei³,Chiu Yu-Lung⁶,Chang Tsung-Hsien⁴,Tsai Pei-Ling³⁴,Lin Ren-Jye⁷,Shih Chih-Chin⁸,Tsai Yi-Jing⁴,Lin Gu-Jiun⁹^ORCID,Yen Li-Chen⁴

Affiliation:

1. Penghu Branch of Tri-Service General Hospital, Penghu, Taiwan, Republic of China

2. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China

3. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan, Republic of China

4. Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, Republic of China

5. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China

6. School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China

7. National Mosquito-Borne Diseases Control Research Center, National Health Research Institute, Miaoli, Taiwan, Republic of China

8. Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, Republic of China

9. Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, Republic of China

Abstract

Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus, and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of effort, we have no clinically specific therapeutic drugs against DENV and ZIKV. Previous studies showed that inflammatory responses play a critical role in dengue and Zika virus pathogenesis.

Funder

National Defense Medical Affairs Bureau

Ministry of Science and Technology, Taiwan

Tri-Service General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00941-19

Reference39 articles.

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2. Dengue

3. Immune Response to Dengue Virus and Prospects for a Vaccine

4. An update on Zika virus infection

5. Zika Virus

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