Affiliation:
1. Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033
Abstract
ABSTRACT
Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC
50
of 0.125 μg/ml and an MIC
90
of 1 μg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2× MIC after 48 h.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
18 articles.
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