Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections

Author:

Drury Sydney L.1,Miller Anderson R.1,Laut Clare L.12,Walter Alec B.34,Bennett Monique R.15,Su Meng6,Bai Mingfeng678,Jing Bingwen9,Joseph Scott B.9,Metzger Edward J.9,Bane Charles E.9,Black Chad C.9,Macdonald Mary T.9,Dutter Brendan F.10,Romaine Ian M.10,Waterson Alex G.101112,Sulikowski Gary A.101112,Jansen E. Duco34,Crowe James E.12513ORCID,Sciotti Richard J.9,Skaar Eric P.12ORCID

Affiliation:

1. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA

4. Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, Tennessee, USA

5. Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA

7. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA

8. Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

9. Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

10. Department of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA

11. Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA

12. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA

13. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Staphylococcus aureus is a serious threat to public health due to the rise of antibiotic resistance in this organism, which can prolong or exacerbate skin and soft tissue infections (SSTIs). Methicillin-resistant S. aureus is a Gram-positive bacterium and a leading cause of SSTIs.

Funder

HHS | National Institutes of Health

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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