Prophylactic Effect of Dietary Seaweed Fucoidan against Enteral Prion Infection-Reference-Cited by-同舟云学术

Prophylactic Effect of Dietary Seaweed Fucoidan against Enteral Prion Infection

Published:2007-06 Issue:6 Volume:51 Page:2274-2277
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Doh-ura Katsumi¹,Kuge Tomoko²,Uomoto Miyuki¹,Nishizawa Keiko¹,Kawasaki Yuri¹,Iha Masahiko³

Affiliation:

1. Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan

2. Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

3. South Product Ltd., Okinawa, Japan

Abstract

ABSTRACT Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00917-06

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5. Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models

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