Population-Based Survey of Antimicrobial Susceptibility and Serotype Distribution of Streptococcus pneumoniae from Meningitis Patients in Salvador, Brazil

Author:

Reis Joice Neves12,Cordeiro Soraia Machado1,Coppola Steven J.3,Salgado Kátia4,Carvalho Maria G. S.5,Teixeira Lúcia M.5,Thompson Terry A.6,Facklam Richard R.6,Reis Mitermayer G.1,Ko Albert I.13

Affiliation:

1. Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde

2. Faculdade de Farmácia, Universidade Federal da Bahia

3. Division of International Medicine and Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021

4. Hospital Couto Maia, Secretaria da Saúde do Estado da Bahia, Salvador

5. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

6. Streptococcus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

Abstract

ABSTRACT Penicillin-nonsusceptible strains were isolated from 15% of 303 individuals with pneumococcal meningitis identified during a 4-year surveillance study in Salvador, Brazil. The estimated rate of coverage of the seven-valent conjugate vaccine was 74% among patients <5 years of age and 94% among those infected with nonsusceptible isolates, indicating that the use of conjugate vaccines may be an approach to the control of emerging penicillin resistance in Brazil.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference26 articles.

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4. Committee on Infectious Diseases of the American Academy of Pediatrics. 1997. Therapy for children with invasive pneumococcal infections. Pediatrics99:289–299.

5. Critchley, I. A., C. Thornsberry, G. Piazza, M. Jones, M. L. Hickey, A. L. Barth, C. Mendes, F. F. Rossi, H. S. Sader, L. M. Teixeira, and D. F. Sahm. 2000. Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis collected from five centers in Brazil, 1997–98. Clin. Microbiol. Infect.6:178–184.

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