Primary Meningoencephalitis by Naegleria fowleri : First Reported Case from Mangalore, South India

Author:

Shenoy Shalini1,Wilson Godwin1,Prashanth H. V.1,Vidyalakshmi K.1,Dhanashree B.1,Bharath R.1

Affiliation:

1. Department of Microbiology, Kasturba Medical College, Mangalore, Karnataka, 575001, India

Abstract

ABSTRACT A fatal case of primary amebic meningoencephalitis (PAM) in a 5-month-old infant is described. The disease may have been contracted during bathing. The source of water was from an artificial well. The clinical presentation, the isolation of the ameba from the cerebrospinal fluid, the poor response to amphotericin B, and the ultimate fatal outcome are all consistent with the diagnosis of PAM. On the basis of its ability to grow at temperatures above 30°C, the morphology of the trophozoite, and the presence of flagellate forms, the ameba was identified as Naegleria fowleri . Pathogenic N. fowleri amebae were recovered from samples of water from the well. To our knowledge this case represents the second case of PAM in an infant in the absence of the history of swimming.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference7 articles.

1. Cerva, L. 1986. Amoebic meningoencephalitis, p.1095–1098. In A. I. Braude, C. E. Davis, and J. Fierer (ed.), Infectious diseases and medical microbiology, 2nd ed. The W. B. Saunders Co., Philadelphia, Pa.

2. Lawande, R. V., I. John, R. H. Dobbs, and L. J. Egler. 1979. A case of primary amebic meningoencephalitis in Zaria, Nigeria. Am. J. Clin. Pathol.71:591–594.

3. Biology of Naegleria spp

4. Waterborne protozoan pathogens

5. Martinez, A. J. 1993. Free-living amebas: infection of the central nervous system. Mt. Sinai J. Med.60:271–278.

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