Assessment of a Combined Testing Strategy for Detection of Antibodies to Human Herpesvirus 8 (HHV-8) in Persons with Kaposi's Sarcoma, Persons with Asymptomatic HHV-8 Infection, and Persons at Low Risk for HHV-8 Infection-Reference-Cited by-同舟云学术

Assessment of a Combined Testing Strategy for Detection of Antibodies to Human Herpesvirus 8 (HHV-8) in Persons with Kaposi's Sarcoma, Persons with Asymptomatic HHV-8 Infection, and Persons at Low Risk for HHV-8 Infection

Published:2002-10 Issue:10 Volume:40 Page:3822-3825
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Casper Corey¹,Krantz Elizabeth²,Taylor Heather²,Dalessio Julie²,Carrell David²,Wald Anna¹²³,Corey Lawrence¹²⁴,Ashley Rhoda²

Affiliation:

1. Departments of Medicine

2. Laboratory Medicine

3. Epidemiology, University of Washington School of Medicine

4. Program in Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, Washington

Abstract

ABSTRACT The performance of a human herpesvirus 8 (HHV-8) enzyme immunoassay (EIA) and selective subsequent use of an HHV-8 immunofluorescence assay (IFA) was tested in persons unlikely to be infected with HHV-8 and those who had HHV-8 detected in their saliva. The IFA was performed on samples within a range of EIA optical densities (0.15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.40.10.3822-3825.2002

Reference16 articles.

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