Molecular Typing of Treponema pallidum in South Africa: Cross-Sectional Studies

Author:

Pillay A.1,Liu H.1,Ebrahim S.2,Chen C. Y.1,Lai W.1,Fehler G.34,Ballard R. C.1,Steiner B.1,Sturm A. W.2,Morse S. A.1

Affiliation:

1. Centers for Disease Control and Prevention, Atlanta, Georgia

2. Department of Medical Microbiology, Africa Centre for Population Studies and Reproductive Health, Medical Research Council Genital Ulcer Disease Research Unit, University of Natal Medical School, Durban, South Africa

3. National Reference Centre for Sexually Transmitted Diseases, Department of Clinical Microbiology and Infectious Diseases, University of Witwatersrand

4. South African Institute of Medical Research, Johannesburg, South Africa

Abstract

ABSTRACT We evaluated a molecular subtyping system for Treponema pallidum for its ability to differentiate between strains obtained from male patients with primary syphilis in South Africa. Of 201 T . pallidum -positive specimens, 161 were typeable, revealing 35 subtypes. The unique subtypes identified in Durban, Cape Town, and Carletonville and the total number of subtypes suggested that the strain population was very diverse and varied geographically.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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