The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis-Reference-Cited by-同舟云学术

The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Puumala Emily¹,Zaslaver Olga¹²,Chen Amy³,Duncan Dustin¹,Fogal Meea⁴,Shapiro Rebecca S.⁴^ORCID,Mazhab-Jafari Mohammad T.³,Whitesell Luke¹,Montenegro-Burke J. Rafael¹²,Robbins Nicole¹,Cowen Leah E.¹^ORCID

Affiliation:

1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

2. Donnelly Centre for Cellular and Molecular Research, University of Toronto, Toronto, Ontario, Canada

3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

4. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

Abstract

As widespread antimicrobial resistance threatens to propel the world into a postantibiotic era, there is a pressing need to identify mechanistically distinct antimicrobial agents. This is of particular concern when considering the limited arsenal of drugs available to treat fungal infections, coupled with the emergence of highly drug-resistant fungal pathogens, including Candida auris .

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02730-22

Reference79 articles.

1. Hidden Killers: Human Fungal Infections

2. Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond