Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology-Reference-Cited by-同舟云学术

Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lienard Julia¹,Munke Kristina²,Wulff Line³,Da Silva Clément²,Vandamme Julien³,Laschanzky Katie¹,Joeris Thorsten²,Agace William²³,Carlsson Fredric¹^ORCID

Affiliation:

1. Microbiology Group, Molecular Cell Biology Unit, Department of Biology, Lund University, Lund, Sweden

2. Mucosal Immunology Group, Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden

3. Mucosal Immunology Group, Department of Health Technology, Technical University of Denmark, Kemitorvet, Denmark

Abstract

The ESX-1 type VII secretion system is required for virulence of pathogenic mycobacteria, including Mycobacterium tuberculosis . ESX-1 interacts with infected macrophages, but its potential roles in regulating other host cells and immunopathology have remained largely unexplored.

Funder

Swedish Research Council

Alfred Österlunds Stiftelse

IngaBritt och Arne Lundbergs Forskningsstiftelse

Knut och Alice Wallenbergs Stiftelse

Kungliga Fysiografiska Sällskapet i Lund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02764-22