Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis-Reference-Cited by-同舟云学术

Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kung Yu-An¹,Chiang Huan-Jung¹,Li Mei-Ling²,Gong Yu-Nong¹³,Chiu Hsin-Ping¹,Hung Chuan-Tien¹^ORCID,Huang Peng-Nien¹⁴,Huang Sheng-Yu¹,Wang Pei-Yu¹,Hsu Tsu-An⁵,Brewer Gary²,Shih Shin-Ru¹³⁶⁷^ORCID

Affiliation:

1. Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan City, Taiwan

2. Department of Biochemistry & Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

3. Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

4. Division of Infectious Diseases, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan

5. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan

6. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

7. Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan

Abstract

We provide the first evidence for the role of ACSL4 in enterovirus replication organelle formation. Moreover, both enteroviruses and coronaviruses induce ferroptosis via ACSL4. These findings establish a novel regulatory mechanism for viral replication. The inhibition of ACSL4 by ferroptosis inhibitors can reduce viral yields of enteroviruses and coronaviruses, including SARS-CoV-2, implying that ACSL4-mediated ferroptosis is a promising therapeutic target for viral diseases.

Funder

National Health Research Institutes

Chang Gung Memorial Hospital, Linkou

Ministry of Science and Technology, Taiwan

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02717-21

Reference45 articles.